Overexpression of TRIM16 Reduces the Titer of H5N1 Highly Pathogenic Avian Influenza Virus and Promotes the Expression of Antioxidant Genes through Regulating the SQSTM1-NRF2-KEAP1 AxisArticle Published on 2023-01-302023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] AIV Nrf2 oxidative stress TRIM16 ubiquitination. [DOI] 10.3390/v15020391 PMC 바로가기
Selection of Ideal Reference Genes for Gene Expression Analysis in COVID-19 and MucormycosisArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] COVID-19 CypA Gene Expression IL-6 Mucormycosis Nrf2 qRT-PCR reference gene. SARS-CoV-2 [DOI] 10.1128/spectrum.01656-22 PMC 바로가기
Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive DeclineReview Published on 2022-10-092023-07-11 Journal: Frontiers in bioscience (Elite edition) [Category] COVID19(2023년), [키워드] Alzheimer's disease Anti-inflammatory Anti-oxidant anti-viral phytochemicals ARDS chalcones cognition and memory flavones long COVID disease Neuroinflammation neuroprotection. Nrf2 Parkinson's Disease SARS-CoV-2 [DOI] 10.31083/j.fbe1404027 PMC 바로가기 [Article Type] Review
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 SIRT1. sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2SARS-CoV-2의 스파이크 단백질은 지질 대사를 손상시키고 지방독성에 대한 감수성을 증가시킵니다: Nrf2의 역할에 대한 의미Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations autophagic autophagic pathway autophagy Cell cell line cell membrane cell membranes control cell control cells controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose-dependent manner dysregulation exhibited expression expression profile Ferroptosis Gene Expression Gene expression profiles HEK293 host cells impair increase inhibitor investigated Lipid lipid metabolism lipotoxicity mechanism metabolism molecules multifunctional Necrosis Nrf2 nuclear palmitic acid pathway Patient Protein role SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant increase spike Spike protein spike protein. suppressed susceptibility the Spike transcriptional trigonelline upregulation was used [DOI] 10.3390/cells11121916 PMC 바로가기 [Article Type] Article
How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 교란된 산화 균형을 회복하는 방법Review Published on 2022-06-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin antioxidant antioxidants Antioxidative balance caused Clinical studies clinical study complex coronavirus coronavirus 2019 disease Course COVID-19 COVID-19 pathogenesis cytokine Cytokine storm demonstrated detrimental disease Disrupted drug dysregulated Effect expression glutathione GSH homeostasis Immunological response Impact induce Inflammasome inflammasomes inhibit mechanism NLRP3 Nrf2 nuclear outcome oxidative oxidative stress oxidative stress. oxygen Prevent Protective Protein protein 3 reactive oxygen species reactive oxygen specy Renin renin angiotensin system ROS SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown stimulate the disease variant variety virus [DOI] 10.3390/ijms23126377 PMC 바로가기 [Article Type] Review
Oxidative stress and decreased Nrf2 level in pediatric patients with COVID-19Article Published on 2022-05-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] COVID 19 Nrf2 oxidative stress pediatrics. [DOI] 10.1002/jmv.27640 PMC 바로가기
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory DiseasesReview Published on 2022-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] advance Agonism agonist antioxidant application Autoimmune diseases Cell cell damage cellular clinical Clinical practice clinical trials complications Coordinate diabete Diabetic disease disorders dysfunction Enzymes Evidence expression of gene fat homeostasis implication Inflammation Inflammatory bowel disease inflammatory disease metabolic metabolic disease molecular Nrf2 obesity organism oxidative stress Pathogenesis pathway Potential Protein recent regulated Regulation Stress therapeutic use tissue transcription factor understanding [DOI] 10.3390/ijms23052846 PMC 바로가기 [Article Type] Review
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevitySirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다Review Published on 2022-03-012022-09-11 Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography echocardiography. Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn [DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review
“LONG COVID”-A hypothesis for understanding the biological basis and pharmacological treatment strategy"LONG COVID"-생물학적 기초 및 약리학적 치료 전략 이해를 위한 가설Review Published on 2022-02-012022-09-11 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 치료제, [키워드] “LONG COVID”. ACE-2 activate activator antioxidant Asymptomatic battery binding biological basis blood vessel blood vessels cause clinical study clinical trial Cohort cough COVID-19 cytokine Depression diagnosed disease drug elevated eliminated Endothelial cell endothelial cells Endothelium enzyme Enzymes evaluate expression fatigue free radical Free radicals glutathione Human Hypothesis hypoxia Inflammation Insomnia longitudinal Loss of Smell loss of smell and/or taste marker melatonin non-infected normal activity Nrf2 nuclear option oxidative oxidative stress oxygen Pain pathology pharmacological treatment proportion Protein reactive oxygen species replicate Replication required Safe SARS-CoV-2 SARS-CoV-2 virus severe pneumonia Shortness of breath subject subjects Symptom Symptoms syndrome Tachycardia Taste these cell These cells tissue tissue hypoxia transcription factor variety Viral viral replication virus were infected [DOI] 10.1002/prp2.911 PMC 바로가기 [Article Type] Review